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Wednesday, November 27, 2019

Amino Acid Methionine Flag: M Flag or Met Flag

The Methionine flag uses the colours red, yellow, black and mustard-yellow.  The vertical stripes along the hoist refer to letter M, which is the single letter abbreviation for this amino acid.   The letter M is represented by red and yellow since these two colours make up the number 13 in colour metrics and M is the 13th letter in the alphabet.  Red is the first colour of the rainbow, so it represents 1.  Yellow is the third colour of the rainbow, so it represents 3.

Methionine has sulfur in its R-Group.  Consequently the field in mustard-yellow.  Pure sulfur power is yellow, and if you ever smelled that rotten egg smell, it is due to this amino acid.  These sulfur amino acids make up proteins in our hair, and if ever got a perm you would have smelled that eggy stink.  It comes about in the breaking of sulfur bonds in ones hair.

Methionine is famous in biology class because the codon is a START signal to create a new protein from the 22 known amino acids; or rather a protein-fairy from the known 22 fairy fibers.  Once the protein (fairy) is finished it will do cellular magic and make life possible.





Amino Acid Leucine Flag: L Flag or Leu Flag

The Leucine Flag uses the colours white, red, orange, and black.  The vertical stripes by the hoist refer to the 12th letter of the alphabet, which is L.  And L is the one letter symbol for Leucine.  Leucine also has a three letter abbreviation: Lys.  Why do the colours red and orange represent L?  Since red is the first colour of the standard rainbow it represents the number 1.  Likewise the second colour of the typical rainbow is orange.  Put them together in colour metrics and they represent 12.

On the field are four dots that reflect the number of carbon atoms in the R-Group, which gives each amino acid its personality.  The pattern is also reflective of L's structure.  The bottom dot represents this amino acids connection to the root of COCON, while the upper part represent the branching pattern outwards.  Note that Hydrogens are ignored in this flag as well.

The primary disease associated with amino acid is Maple Syrup Urine Disease, which is an inherited disease.  People with this disorder can not break down branched amino acids like Leucine, among others.  This can lead to death if not treated properly.  The treatment is a careful diet regulation and ultimately a liver transplant.




Amino Acid Lysine Flag: K Flag or Lys Flag

The flag for Lysine uses the common colours of red, white, and blue.  And no, these colours don't run.  But they can dissolve in water.  The square blue field indicates that Nitrogen is present in the R-Group.  There is only one Nitrogen to be exact.  Also the four dots indicate four Carbons in the R-Group.  The patterns also demonstrates the singular long chain structure.

Along the hoist are two vertical red stripes and one thin white stripe.  This pattern refers to the fact that the official single letter symbol for Lysine is K.  Why not 'L'?  Because 'L' is taken by another amino acid: Leucine.  To decode the hoist stripes, K is coded to the number 11 because it is the 11th letter of the alphabet and the number 1 is coded to red.  Why red?  Because the first colour of the standard rainbow is red.  Thus two red stripes symbolize 11.  And white is assigned contrast indicator, so the white stripe brings contrast, otherwise it'd just look one one red block.

K'lysine was discovered in 1902 by two German alchemists Emil Fischer and Fritz Weigert.  Fischer is perhaps more famous for his eponymous Fischer Projections of molecules.  Just think of the those diagrams as having fishing lines between atoms and such.  Emil is also the founder-highest of high alchemists of IUPAC, since it was his idea.

Lysine became famous in 1993 in the movie Jurrasic Park.  It was mentioned as the kill switch, which was a required supplement needed for their survival.  So when they cloned the dinosaurs the Jurassigineers disabled the dinosaurs metabolic ability to make Lysine.  But as you know, nature has a way of overcoming barriers. Life made it to Hawaii long before humans did, after all.



Amino Acid Isoluecine Flag: Ile Flag or I Flag

The Isoleucine flag uses the colours pink, white, and black.  The black square field indicates there are neither Nitrogens nor Oxygens in the R-Group, only Carbon (Hydrogens are ignored).  The order of the dots also reflects the structure.  The lowest dot represents the connection point to the COCON root.  The two dots along the fly indicate the two carbon stem, while the dot next to pink stripe represents the short, one carbon stem.

The white and pink stripe reflect the letter I.  Reason being I is the 9th letter in the alphabet and the number 9 is represented by the colour pink in colour metrics.

Isoleucine was discovered in Germany in the year 1903 by Felix Ehrlich.  Perhaps the most famous disease linked to amino acid I is Maple Syrup Urine Disease.  Although the name may sound funny, the consequences are deadly if not treated properly. As the name implies, MSUD, is when ones urine smells like maple syrup.


Amino Acid Histidine Flag: His Flag or H Flag

The Histidine flag uses the colours black, white, and blue.  The square blue field indicates it has Nitrogen in its R-Group (2 Nitrogens to be exact).  The four white dots indicate that there are 4 carbons in the R-Group.  Since carbons are the 'most important' atom in living system, they get chief representation in dots in Amino Acid Dice Symbols.  The vertical white and black stripe along the hoist represent the letter H.  The letter H is represented by white and black stripe, because H is the 8th letter of the alphabet and 8 is represented by black in colour metrics.  The four white carbon dots in the corner also indicate that this amino acid has a ring structure, thus making aromatic whereby electrons are shared in dreidel like fashion.

Histidine was first discovered in Germany in 1896 by two doctors: Albrecht Kossel and Sven Gustaf Hedin.  The three letter abbreviation is His, but for gender equity sake you can also use Her.  H is often used as 'proton shuttle' which means its like a UPS delivery relay runner for protons.   

Histamine is the most famous cousin of Histidine, a slightly modified version of the amino acid Her.  After all a female UPS driver can work just as hard and fast a male UPS driver, and without the obsessive need to check sports scores.   


Amino Acid Glycine Flag: Gly Flag or G Flag

The Glycine flag uses the colours white and purple.  The larger white square field towards the fly indicates that there are no carbons in the R-Group.  In fact only a single hydrogen atom makes up the R-Group.  Essentially it is a single amino acid stem COCON with a hydrogen attached to it, make it the Solo Hydro Amino Acid.  Amino Acid flag usually dice like pattern in the field but Glycine is blank.  If you ever played with a chemistry model kit, hydogens are usually coloured white, thus a blank white field.  Likewise white light from the Sun is formed from the fusion of hydrogen into heavier elements.

The purple vertical stripe indicates the letter G, which is the single letter symbol for this amino acid.  Why is purple associated with G?  Because the seventh colour of the rainbow is purple and the letter G is the seventh letter of the alphabet.

Glycine was discovered in France in the year 1820 by Henri Baconnot.  Braconnot was one of the early pioneers who was able to turn wood, cotton, and straw into table sugar.  He also discovered that fungi contian chitin.  




Amino Acid Phenylalanine Flag: Phe Flag or F Flag

The Phenylalanine flag uses the colours blue, white, and black.  The field has seven white dots to represent the seven carbons on the R-Group.  Usually this amino acid is listed as having nine carbons, but the two carbons on the CONCO stem, since they are all the same. The black field indicates that there is no Nitrogen nor Oxygen in the R-Group.  Along the fly are white and blue vertical stripes.  These stripes indicate the letter F, because the single letter notation for this amino acid is officially F.  The letter F is coded to white and blue, since F is the 6th letter of the alphabet and dark blue (indigo) is the sixth colour of the rainbow.  White is coded to zero, so the vertical stripes read 06, which traces it to sixth letter, F—the one letter symbol for Phenylalanine.  Amino Acid F also has a three letter abbreviation Phe.  Since all four corners of the field have a dot, this indicates that it has ring structure.

Phe was discovered in 1879 by Ernst Schulez who was born in Saxony, Germany.  When Schulez was in Switzerland's Zürich, his team discovered Phenylalanine. Also note the name resembles the amino acid Alanine.  Thus Phenyl-Alanine is simply single Alanine with a Phenyl group attached to it; they could have called it Alaphenyline. You can think of the central dot on the field being the lone Alanine carbon, while the 'six' of dots represents the aromatic ringlike Phenyl part.

Phenylalanine may have made its most famous footnote the public mind during high school biology, if you studied inherited rare genetic diseases.  The genetic disorder associated with Phenylalanine is known as PKU.  Perhaps the most famous person associated with this order is Pearl S. Buck.  Pearl had a daughter who suffered from this affliction.  Basically persons with PKU have an inability to process this amino acid.  After a while it builds up in their system and leads to mental retardation.  Then in 1934 a Norwegian physician Ivar Asbjørn Følling came to understand this disease.   Finally in 1954, Horst Bickel, Evelyn Hickmans and John Gerrard discovered how to treat this disorder with a special diet that did not include Phenylalanine, which lead to recovery and allowed persons born with this inherited genetic disease to stay mentally healthy.  About 30,000 people in the USA have PKU, which means they have a limited diet.  The hard part is, during childhood and adolescence, PKU persons get picked on for not being able to eat 'normal' food.  Most people are aware of people who shouldn't eat Gluten, but PKU people have a more restrictive diet and the consequences for eating standard food is debilitating. Basically PKU people are Obligate Vegans or Natural Herbivores.